CO-DESIGNING THE PEDESTRIAN REVOLUTION IN MUSCAT

Co-designing the pedestrian revolution in Muscat

Abstract Rapid growth coupled with the prevailing land allocation system in Oman led to a shift from compact dwellings typologies to detached single-family houses, arranged in monofunctional zoning systems that exclusively rely on cars.Due to the sprawled transformation, authorities are unable to provide new neighborhoods with basic infrastructure

read more

A Guide to the Implementation and Design of Ex Vivo Perfusion Machines for Vascularized Composite Allotransplantation

Background:.Ex vivo machine perfusion (EVMP) is a versatile platform utilized in vascularized composite allotransplantation (VCA) to prolong preservation, salvage tissue, and evaluate graft viability.However, there is no consensus on Chrome best practices for VCA.This article discusses the common components, modifications, and considerations necess

read more

Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

During tuberculosis (TB), migration of dendritic cells (DCs) from the site of infection to the draining lymph nodes is known to be impaired, hindering the rapid development of protective T-cell-mediated immunity.However, the mechanisms involved in the delayed migration of DCs during TB are still poorly defined.Here, we found that infection of DCs w

read more

Heparanase-1: From Cancer Biology to a Future Antiviral Target

Heparan sulfate proteoglycans (HSPGs) are a major constituent of the extracellular matrix (ECM) and are found to be implicated in viral infections, where they play a role in both cell entry and release for many viruses.The enzyme heparanase-1 is the only known endo-beta-D-glucuronidase capable of degrading heparan sulphate (HS) chains of HSPGs and

read more